HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 730980-52-6
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[(1R,2S)-2,3-Dihydro-2-methyl-1H-inden-1-yl]-2-methoxyacetamide | HCID 66739634 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 730980-52-6 | HCID 66739261 | — |
Reaction Steps
Concentrated hydrochloric acid (8 ml) was added to a solution of N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide (5.9 g, 0.0269 mol) in ethanol and water, and the mixture heated for 12 hours at reflux. The solvent was evaporated and a small amount of ethyl acetate added. The undissolved solid was filtered off to give (1R,2S)-1-amino-2-methylindane hydrochloride (1.0 g) as a solid, chemical purity>95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114991B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a361b52d3240489d809eb2c9b5bb01f2 |
| Source note | uspto-grants-2012_02 |