Hydrochloric Acid → 730980-52-6

HRID 1641379Notes

Reaction equation

HRID 1641379 reaction equation
[ClH:1].[CH3:2][C@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]1[NH:12]C(=O)COC>C(O)C.O>[ClH:1].[NH2:12][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:11][C@@H:3]1[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66739634N-[(1R,2S)-2,3-Dihydro-2-methyl-1H-inden-1-yl]-2-methoxyacetamide

Product 1

HCID 66739261730980-52-6

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Concentrated hydrochloric acid (8 ml) was added to a solution of N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide (5.9 g, 0.0269 mol) in ethanol and water, and the mixture heated for 12 hours at reflux. The solvent was evaporated and a small amount of ethyl acetate added. The undissolved solid was filtered off to give (1R,2S)-1-amino-2-methylindane hydrochloride (1.0 g) as a solid, chemical purity>95%.

Workup

  1. temperaturethe mixture heated for 12 hours
  2. temperatureat reflux
  3. customThe solvent was evaporated
  4. additiona small amount of ethyl acetate added
  5. filtrationThe undissolved solid was filtered off

Sources & evidence

ORD record
ord-a361b52d3240489d809eb2c9b5bb01f2
Source dataset
uspto-grants-2012_02
Patent number
US08114991B2

Reaction notes

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