反应详情

To tert-butyl-1-(3,5-difluoropyridin-2-yl)ethylcarbamate (Method 16; 0.10 g, 0.39 mmol) in DCM (2 ml) was added HCl (0.8 ml, 3.12 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed and 10 ml of saturated sodium bicarbonate was added. The resulting aqueous solution was extracted with ether (5×30 ml), dried over sodium sulfate and concentrated to give the title compound (0.06 g, 95%) as pale yellow oil. MS: Calcd.: 158. Found: [M+H]+ 159.

1. customThe solvent was removed
2. addition10 ml of saturated sodium bicarbonate was added
3. extractionThe resulting aqueous solution was extracted with ether (5×30 ml)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated