Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 24769549, compound

HRID 1641426Notes

Reaction equation

HRID 1641426 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[N:3]=1.Cl.Cl[CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH3:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([O:13][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:9][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11344285HCID 11344285, compound

Product 1

HCID 24769549HCID 24769549, compoundYield 54%

Procedure

The title compound was prepared from 4-(3-methyl-pyrazol-1-yl)-phenol (0.1 g, 0.61 mmol) and 1-(2-chloroethyl)piperidine hydrochloride (0.23 g, 1.25 mmol) using the general procedure C with a yield of 54% (90 mg); 1H NMR (400 MHz, CDCl3) 7.70 (d, J=2 Hz, 1H), 7.52 (d, J=9.2 Hz, 2H), 6.96 (d, J=9.2 Hz, 2H), 6.20 (d, J=2 Hz, 1H), 4.12 (t, J=12, 6 Hz, 2H), 2.78 (t, J=12, 6 Hz, 2H), 2.52 (br, 4H), 2.37 (s, 3H), 1.61-1.47 (m, 6H); LC/MS (ESI): 97%.

Sources & evidence

ORD record
ord-bc58e03511ba4196bdcf2ec160deaf5c
Source dataset
uspto-grants-2012_02
Patent number
US08115005B2

Reaction notes

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