Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 24769549, compound

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Reaction Steps

The title compound was prepared from 4-(3-methyl-pyrazol-1-yl)-phenol (0.1 g, 0.61 mmol) and 1-(2-chloroethyl)piperidine hydrochloride (0.23 g, 1.25 mmol) using the general procedure C with a yield of 54% (90 mg); 1H NMR (400 MHz, CDCl3) 7.70 (d, J=2 Hz, 1H), 7.52 (d, J=9.2 Hz, 2H), 6.96 (d, J=9.2 Hz, 2H), 6.20 (d, J=2 Hz, 1H), 4.12 (t, J=12, 6 Hz, 2H), 2.78 (t, J=12, 6 Hz, 2H), 2.52 (br, 4H), 2.37 (s, 3H), 1.61-1.47 (m, 6H); LC/MS (ESI): 97%.

Provenance & Evidence