Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 23729164, compound

HRID 1641427Notes

Reaction equation

HRID 1641427 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[N:3]=1.Cl.Cl[CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:10][CH:9]=2)[N:3]=1

Participants

3

Reactant 2

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 1301991451011-27-9

Product 1

HCID 23729164HCID 23729164, compoundYield 44%

Procedure

The title compound was prepared from 4-(3,5-dimethyl-pyrazol-1-yl)-phenol (0.1 g, 0.53 mmol), 1-(2-chloroethyl)piperidine hydrochloride (0.2 g, 1.1 mmol) using the general procedure C with a yield of 44% (70 mg); 1H NMR (400 MHz, CDCl3) 7.30 (d, J=8.8 Hz, 2H), 6.95 (d, J=8.8 Hz, 2H), 5.96 (s, 1H), 4.14 (t, J=12, 6 Hz, 2H), 2.78 (t, J=12, 6 Hz, 2H), 2.53 (br, 4H), 2.28 (s, 3H), 2.24 (s, 3H), 1.61-1.47 (m, 6H); LC/MS (ESI): 96%.

Sources & evidence

ORD record
ord-67dea46de43c4494942940cb2ba99144
Source dataset
uspto-grants-2012_02
Patent number
US08115005B2

Reaction notes

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