Thionyl Chloride → HCID 56949532, compound

HRID 1641461Notes

Reaction equation

HRID 1641461 reaction equation
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:10]=[C:9]([C:11](O)=[O:12])[N:8]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[N:7]=1>CN(C)C=O.C1(C)C=CC=CC=1>[Br:5][C:6]1[CH:10]=[C:9]([C:11]([Cl:3])=[O:12])[N:8]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[N:7]=1

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 115875353-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

Product 1

HCID 56949532HCID 56949532, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

1.5 ml of thionyl chloride and 2 drops of dimethylformamide were added to a mixed solution comprising 1.0 g of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid and 10 ml of toluene, followed by reflux with heating for one hour, and thionyl chloride and toluene were distilled off to obtain crude product of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride.

Workup

  1. temperatureby reflux
  2. temperaturewith heating for one hour
  3. distillationthionyl chloride and toluene were distilled off

Sources & evidence

ORD record
ord-11d01995541c4f17808ad1f69109431f
Source dataset
uspto-grants-2012_02
Patent number
US08115006B2

Reaction notes

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