Acetone → HCID 66739094, compound

HRID 1641486Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:25]=3[CH3:31])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[C:4]([CH2:39][CH2:40][CH2:41][C:42]([O-:44])=[O:43])=[C:5]([CH3:38])[N:6]2[CH2:32][CH2:33][CH2:34][C:35]([O-:37])=[O:36].[Na+:45].[Na+].C[OH:48].CC(C)=[O:51]>O>[OH2:19].[OH2:51].[OH2:48].[OH2:19].[OH2:19].[OH2:19].[OH2:19].[OH2:19].[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:25]=3[CH3:31])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[C:4]([CH2:39][CH2:40][CH2:41][C:42]([O-:44])=[O:43])=[C:5]([CH3:38])[N:6]2[CH2:32][CH2:33][CH2:34][C:35]([O-:37])=[O:36].[Na+:45].[Na+:45]

Participants

Conditions

Temperature: 15 °C

Procedure

The compound (10 g) prepared in Example 58 was dissolved in water (20 mL) and methanol (20 mL) at 53° C. To the solution, acetone (750 mL) was added and cooled to 15° C. The precipitated solid was filtered and dried at 40° C. under reduced pressure. The compound was maintained at 75% of relative humidity at 40° C. for 10 days to obtain the title compound (8.2 g) having the following physical properties.

Workup

customat 53° C
filtrationThe precipitated solid was filtered
customdried at 40° C. under reduced pressure
temperatureThe compound was maintained at 75% of relative humidity at 40° C. for 10 days

Sources & evidence

ORD record: ord-4f092ae3396741b992db35b9efbf30d6
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08115014B2

Reaction notes

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