Acetone → HCID 86643011, compound

HRID 1641487Notes

Reaction equation

HRID 1641487 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[C:29]([F:30])=[CH:28][C:27]([F:31])=[C:26]([F:32])[C:25]=3[F:33])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[C:4]([CH2:41][CH2:42][CH2:43][C:44]([O-:46])=[O:45])=[C:5]([CH3:40])[N:6]2[CH2:34][CH2:35][CH2:36][C:37]([O-:39])=[O:38].[Na+:47].[Na+].CO.CC(C)=O>O>[OH2:19].[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[C:29]([F:30])=[CH:28][C:27]([F:31])=[C:26]([F:32])[C:25]=3[F:33])=[CH:15][CH:14]=2)=[C:7]2[C:3]=1[C:4]([CH2:41][CH2:42][CH2:43][C:44]([O-:46])=[O:45])=[C:5]([CH3:40])[N:6]2[CH2:34][CH2:35][CH2:36][C:37]([O-:39])=[O:38].[Na+:47].[Na+:47]

Participants

5

Reactant 3

HCID 180AcetoneHCID 887MethanolHCID 86643012HCID 86643012, compound

Product 1

HCID 86643011HCID 86643011, compoundYield 178.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
2 °C

Procedure

The compound (8.5 g) prepared in Example 59 was dissolved in water (22 mL) and methanol (22 mL) at 60° C. To the solution, acetone (430 mL) was added at room temperature and cooled to 2° C. The precipitated solid was filtered and dried at 50° C. under reduced pressure to obtain the title compound (7.8 g) having the following physical properties.

Workup

  1. customat 60° C
  2. filtrationThe precipitated solid was filtered
  3. customdried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-dc51ed7d3900496a82ee652656c70da7
Source dataset
uspto-grants-2012_02
Patent number
US08115014B2

Reaction notes

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