HCID 57624619, compound → HCID 57624592, compound

HRID 1641540Notes

Reaction equation

HRID 1641540 reaction equation
[C:1]([O:4][CH2:5][C:6]([NH:38][C:39](=[O:41])[CH3:40])([CH2:33][O:34][C:35](=[O:37])[CH3:36])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:24]3[C:19](=[C:20]([O:25]CC4C=CC=CC=4)[CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)(=[O:3])[CH3:2]>C(OCC)(=O)C.CO.[C].[Pd]>[C:35]([O:34][CH2:33][C:6]([NH:38][C:39](=[O:41])[CH3:40])([CH2:5][O:4][C:1](=[O:3])[CH3:2])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:24]3[C:19](=[C:20]([OH:25])[CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)(=[O:37])[CH3:36]

Participants

5

Reactant 1

HCID 57624619HCID 57624619, compound

Product 1

HCID 57624592HCID 57624592, compoundYield 81.6%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

The compound (1.45 g) of Example (1-1) was dissolved in ethyl acetate (30 mL) and methanol (10 mL), 10% palladium carbon (500 mg) was added, and the mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere. After celite filtration, the filtrate was concentrated, and the residue was washed with diethyl ether to give the object product (0.99 g) as white crystals.

Workup

  1. filtrationAfter celite filtration
  2. concentrationthe filtrate was concentrated
  3. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-cc9527716e954987a918fc00db2de0f4
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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