Hydrochloric Acid → HCID 24852154, compound

Participants

Reaction Conditions

Reaction Steps

N-[5-{2-[2′-Fluoro-4′-(3-methylphenylthio)biphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl}acetamide (187 mg) was dissolved in methanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 70° C. for 7 hr. The reaction mixture was concentrated, and the residual crude crystals were suspended in ethyl acetate and collected by filtration to give the title compound (52 mg) as white crystals.

Provenance & Evidence