Hydrochloric Acid → HCID 24852154, compound

HRID 1641547Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]2([NH:32]C(=O)C)[CH2:29][O:28]C(C)(C)[O:26][CH2:25]2)=[CH:18][CH:17]=1.[ClH:36]>CO>[ClH:36].[NH2:32][C:24]([CH2:23][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:3]2[CH:4]=[CH:5][C:6]([S:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)=[CH:7][C:2]=2[F:1])=[CH:21][CH:20]=1)([CH2:29][OH:28])[CH2:25][OH:26]

Participants

Conditions

Temperature: 70 °C

Procedure

N-[5-{2-[2′-Fluoro-4′-(3-methylphenylthio)biphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl}acetamide (187 mg) was dissolved in methanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 70° C. for 7 hr. The reaction mixture was concentrated, and the residual crude crystals were suspended in ethyl acetate and collected by filtration to give the title compound (52 mg) as white crystals.

Workup

concentrationThe reaction mixture was concentrated
filtrationcollected by filtration

Sources & evidence

ORD record: ord-ede3e882a2af499eb8b41f522291fea1
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114902B2

Reaction notes

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