Hydrochloric Acid → HCID 66735929, compound

HRID 1641562Notes

Reaction equation

HRID 1641562 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]4([NH:32]C(=O)C)[CH2:29][O:28]C(C)(C)[O:26][CH2:25]4)=[CH:18][CH:17]=3)=[C:12]([F:36])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[ClH:37]>C(O)C>[ClH:37].[NH2:32][C:24]([CH2:23][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([S:9][C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)=[CH:11][C:12]=2[F:36])=[CH:21][CH:20]=1)([CH2:29][OH:28])[CH2:25][OH:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24852499HCID 24852499, compound

Product 1

HCID 66735929HCID 66735929, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

N-(5-{2-[4′-(3,4-Dimethylphenylthio)-2′-fluorobiphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl)acetamide (0.23 g) was dissolved in ethanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 75° C. for 4 hr. The reaction mixture was concentrated to dryness, and the residual solid was suspended in ethyl acetate and collected by filtration to give the title compound (141 mg) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-cec19d29a710409fb8cf7422b1ce8518
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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