Hydrochloric Acid → HCID 46206436, compound

HRID 1641564Notes

Reaction equation

HRID 1641564 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26]2([NH:34]C(=O)C)[CH2:31][O:30]C(C)(C)[O:28][CH2:27]2)=[CH:20][CH:19]=1.[ClH:38]>C(O)C>[ClH:38].[NH2:34][C:26]([CH2:25][CH2:24][C:21]1[CH:20]=[CH:19][C:18]([C:3]2[CH:4]=[CH:5][C:6]([S:8][C:9]3[CH:10]=[CH:11][C:12]([CH:15]([CH3:16])[CH3:17])=[CH:13][CH:14]=3)=[CH:7][C:2]=2[F:1])=[CH:23][CH:22]=1)([CH2:31][OH:30])[CH2:27][OH:28]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57624609HCID 57624609, compound

Product 1

HCID 46206436HCID 46206436, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

N-(5-{2-[2′-Fluoro-4′-(4-isopropylphenylthio)biphenyl-4-yl]ethyl}-2,2-dimethyl-1,3-dioxan-5-yl)acetamide (0.24 g) was dissolved in ethanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 75° C. for 4 hr. The reaction mixture was concentrated to dryness, and the residual solid was suspended in ethyl acetate and collected by filtration to give the title compound (141 mg) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-b6175d396b694238a4142e78e468df3d
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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