Lithium Hydroxide → HCID 46206781, compound

Participants

Reaction Steps

N-{1,1-Bis(acetoxymethyl)-3-[2′-fluoro-4′-(4-methylphenoxy)biphenyl-4-yl]propyl}acetamide (0.26 g) was dissolved in methanol (10 mL), 1M aqueous lithium hydroxide solution (10 mL) was added, and the mixture was refluxed with stirring for 2 hr. The reaction mixture was concentrated, and the precipitated crystals were collected by filtration. The crude crystals were purified by preparative HPLC to give the title compound (59 mg) as white crystals.

Provenance & Evidence