反应详情

N-{1,1-Bis(acetoxymethyl)-3-[2′-fluoro-4′-(4-methylphenoxy)biphenyl-4-yl]propyl}acetamide (0.26 g) was dissolved in methanol (10 mL), 1M aqueous lithium hydroxide solution (10 mL) was added, and the mixture was refluxed with stirring for 2 hr. The reaction mixture was concentrated, and the precipitated crystals were collected by filtration. The crude crystals were purified by preparative HPLC to give the title compound (59 mg) as white crystals.

1. temperaturethe mixture was refluxed
2. concentrationThe reaction mixture was concentrated
3. filtrationthe precipitated crystals were collected by filtration
4. customThe crude crystals were purified by preparative HPLC