Hydrochloric Acid → HCID 57624588, compound

Participants

Reaction Conditions

Reaction Steps

N-{5-[2-(4′-Bromo-2′-fluorobiphenyl-4-yl)ethyl]-2,2-dimethyl-1,3-dioxan-5-yl}acetamide (2.50 g) of Reference Example 10 was dissolved in ethanol (50 mL), concentrated hydrochloric acid (25 mL) was added, and the mixture was stirred at 80° C. for 4 hr. The reaction mixture was concentrated, and neutralized with 1M aqueous sodium hydroxide solution. The precipitated crystals were collected by filtration to give the title compound (1.36 g) as white crystals.

Provenance & Evidence