Hydrochloric Acid → HCID 57624588, compound

HRID 1641574Notes

Reaction equation

HRID 1641574 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]3([NH:24]C(=O)C)[CH2:21][O:20]C(C)(C)[O:18][CH2:17]3)=[CH:10][CH:9]=2)=[C:4]([F:28])[CH:3]=1.Cl>C(O)C>[NH2:24][C:16]([CH2:15][CH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=2[F:28])=[CH:9][CH:10]=1)([CH2:21][OH:20])[CH2:17][OH:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46203835HCID 46203835, compound

Product 1

HCID 57624588HCID 57624588, compoundYield 66.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

N-{5-[2-(4′-Bromo-2′-fluorobiphenyl-4-yl)ethyl]-2,2-dimethyl-1,3-dioxan-5-yl}acetamide (2.50 g) of Reference Example 10 was dissolved in ethanol (50 mL), concentrated hydrochloric acid (25 mL) was added, and the mixture was stirred at 80° C. for 4 hr. The reaction mixture was concentrated, and neutralized with 1M aqueous sodium hydroxide solution. The precipitated crystals were collected by filtration to give the title compound (1.36 g) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-0149a10e1e174517946527edb8c509aa
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

Loading…