Hydrochloric Acid → HCID 66736810, compound

Participants

Reaction Conditions

Reaction Steps

N-[1,1-Bis(acetoxymethyl)-3-(4′-bromo-3-chloro-2′-fluorobiphenyl-4-yl)propyl]acetamide (0.50 g) of Reference Example 23 was dissolved in methanol (10 mL), concentrated hydrochloric acid (5 mL) was added, and the mixture was stirred at 80° C. for 3 hr. The reaction mixture was concentrated to dryness, and the residual solid was suspended in diisopropyl ether and collected by filtration to give the title compound (0.38 g) as white crystals.

Provenance & Evidence