Hydrochloric Acid → HCID 66736810, compound

HRID 1641578Notes

Reaction equation

HRID 1641578 reaction equation
C([O:4][CH2:5][C:6]([NH:29]C(=O)C)([CH2:24][O:25]C(=O)C)[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][C:16]=2[F:22])=[CH:11][C:10]=1[Cl:23])(=O)C.Cl>CO>[ClH:23].[NH2:29][C:6]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][C:16]=2[F:22])=[CH:11][C:10]=1[Cl:23])([CH2:5][OH:4])[CH2:24][OH:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46203836HCID 46203836, compound

Product 1

HCID 66736810HCID 66736810, compoundYield 183%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

N-[1,1-Bis(acetoxymethyl)-3-(4′-bromo-3-chloro-2′-fluorobiphenyl-4-yl)propyl]acetamide (0.50 g) of Reference Example 23 was dissolved in methanol (10 mL), concentrated hydrochloric acid (5 mL) was added, and the mixture was stirred at 80° C. for 3 hr. The reaction mixture was concentrated to dryness, and the residual solid was suspended in diisopropyl ether and collected by filtration to give the title compound (0.38 g) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. filtrationcollected by filtration

Sources & evidence

ORD record
ord-587f604cf27f473390fb7fb523fb4d0c
Source dataset
uspto-grants-2012_02
Patent number
US08114902B2

Reaction notes

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