HCID 57652073, compound → HCID 57652026, compound

HRID 1641784Notes

Reaction equation

HRID 1641784 reaction equation
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

Participants

4

Reactant 3

HCID 57652073HCID 57652073, compoundHCID 66738250HCID 66738250, compoundHCID 66738402HCID 66738402, compound

Product 1

HCID 57652026HCID 57652026, compound

Procedure

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

Workup

  1. customThis material was directly used in the next step without further purification

Sources & evidence

ORD record
ord-c6511dc442f547b4a4b1e6b96b589a2d
Source dataset
uspto-grants-2012_02
Patent number
US08115011B2

Reaction notes

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