Iodoethane → HCID 85875949, compound

HRID 1641894Notes

Reaction equation

HRID 1641894 reaction equation
[CH:1]1[N:2]=[CH:3][N:4]2[C:9]=1[CH2:8][CH2:7][NH:6][C:5]2=[O:10].[CH2:11]([I:13])[CH3:12]>C(#N)C>[I-:13].[CH2:11]([N+:2]1[CH:1]=[C:9]2[N:4]([C:5](=[O:10])[NH:6][CH2:7][CH2:8]2)[CH:3]=1)[CH3:12]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 14875185H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

Product 1

HCID 85875949HCID 85875949, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
120 °C

Procedure

7,8-Dihydro-6H-imidazo[1,5-c]pyrimidin-5-one (1.00 g, 7.30 mmol) and ethyl iodide (3.42 g, 21.90 mmol) are placed in a 10-20 mL microwave vial. Acetonitrile (10 mL) is added and the reaction mixture is heated to 120° C. using microwave radiation. The reaction is shown to be complete by NMR after 1 hour. The crystalline material is filtered off and washed with ice-cold acetonitrile to give the title compound. 1H nmr (MeOD, 400 MHz); 7.60 (s, 1H), 4.35 (q, 2H), 3.65 (t, 2H), 3.15 (t, 2H), 1.60 (t, 3H).

Workup

  1. filtrationThe crystalline material is filtered off
  2. washwashed with ice-cold acetonitrile

Sources & evidence

ORD record
ord-049e43d6b51c44ba9f23682b8a8832fd
Source dataset
uspto-grants-2012_02
Patent number
US08114877B2

Reaction notes

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