反应详情

A mixture of 3.0 grams (0.0057 mole) of tert-butyl 4-{bis[4-(trifluoromethoxy)phenyl]methyl}-4-hydroxypiperidine carboxylate and 25 mL of methylene chloride was chilled in a wet ice bath. A solution of 2.63 mL trifluoro acetic acid and 5 mL methylene chloride was added dropwise to the reaction mixture during a 5-minute period. The wet ice bath was removed and the reaction mixture was allowed to warm to ambient temperature. The reaction mixture was then warmed to reflux, and allowed to cool to ambient temperature. The reaction mixture was concentrated under reduced pressure. The residue can then be dissolved in 100 mL methylene chloride and reacted with 200 mL of an aqueous solution saturated with sodium carbonate. The methylene chloride layer can then be separated, dried over magnesium sulfate, filtered and concentrated under reduced pressure to yield the subject compound.

1. temperaturewas chilled in a wet ice bath
2. customThe wet ice bath was removed
3. temperatureThe reaction mixture was then warmed
4. temperatureto reflux
5. temperatureto cool to ambient temperature
6. concentrationThe reaction mixture was concentrated under reduced pressure
7. dissolutionThe residue can then be dissolved in 100 mL methylene chloride
8. customreacted with 200 mL of an aqueous solution saturated with sodium carbonate
9. customThe methylene chloride layer can then be separated
10. dry with materialdried over magnesium sulfate
11. filtrationfiltered
12. concentrationconcentrated under reduced pressure
13. customto yield the subject compound