Hydrogen Bromide → HCID 178419266, compound

Participants

Reaction Conditions

Reaction Steps

5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine (5.0 g, 27.6 mmol) was dissolved in 30% hydrogen bromide in acetic acid (50 ml). The mixture was stirred at 130° C. for 3 hours and cooled to room temperature, and then the solvents were removed in vacuo and the residue was solidified with diethyl ether to give 2-amino[1,3]thiazolo[5,4-b]pyridin-5-ol dihydrobromide (9.11 g, quantitatively) as colorless crystals.

Provenance & Evidence