Hydrogen Bromide → HCID 178419266, compound

HRID 1642049Notes

Reaction equation

HRID 1642049 reaction equation
C[O:2][C:3]1[N:8]=[C:7]2[S:9][C:10]([NH2:12])=[N:11][C:6]2=[CH:5][CH:4]=1.[BrH:13]>C(O)(=O)C>[BrH:13].[BrH:13].[NH2:12][C:10]1[S:9][C:7]2[C:6]([N:11]=1)=[CH:5][CH:4]=[C:3]([OH:2])[N:8]=2

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 28015575-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine

Product 1

HCID 178419266HCID 178419266, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
130 °C

Procedure

5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine (5.0 g, 27.6 mmol) was dissolved in 30% hydrogen bromide in acetic acid (50 ml). The mixture was stirred at 130° C. for 3 hours and cooled to room temperature, and then the solvents were removed in vacuo and the residue was solidified with diethyl ether to give 2-amino[1,3]thiazolo[5,4-b]pyridin-5-ol dihydrobromide (9.11 g, quantitatively) as colorless crystals.

Workup

  1. temperaturecooled to room temperature
  2. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-11f509bc993b4e0eb036ac074b05cf91
Source dataset
uspto-grants-2012_02
Patent number
US08119626B2

Reaction notes

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