HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1642092Generated: October 25, 2026
Nitric Acid → 7-nitro-5H-pyrrolo[2,3-b]pyrazine
https://huagongshe.com/reaction/1642092
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5H-Pyrrolo[2,3-b]pyrazine | HCID 5370803 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-nitro-5H-pyrrolo[2,3-b]pyrazine | HCID 12207192 | — |
Reaction Steps
7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared by adding 5H-pyrrolo[2,3-b]pyrazine (3) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 7-nitro-5H-pyrrolo[2,3-b]pyrazine 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08119637B2 |
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| Source dataset | uspto-grants-2012_02 |
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| ORD ID | ord-154cf4acfdd640b3a18fb50da19058f6 |
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| Source note | uspto-grants-2012_02 |
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