反应详情

2-(2-(3,4-Dichlorophenylsulfonamido)phenyl)acetic acid methyl ester (14.3 g, 38.21 mmol) and methyl iodide (8.2 ml, 132.25 mmol) were dissolved in acetone (300 ml); K2CO3 (7.3 g, 52.90 mmol) was added thereto, and stirring was carried out overnight at 40° C. in a closed flask. The suspension was cooled and then filtered, concentrated, filtered over silica gel (eluant DCM) and concentrated.

1. temperatureThe suspension was cooled
2. filtrationfiltered
3. concentrationconcentrated
4. filtrationfiltered over silica gel (eluant DCM)
5. concentrationconcentrated