反应详情

Lithium hydroxide (0.75 mg, 18 mmol) was added to a cooled solution of methyl 2-(1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)acetate (2.1 g, 6 mmol) in methanol (20 ml) and water (20 ml), and stirring was carried out for 16 h at room temperature (TLC monitoring). The solvent was removed using a rotary evaporator and the residue was taken up in water. The aqueous phase was washed with ethyl acetate and acidified with 1 M HCl, and then the product was extracted with ethyl acetate and the organic phase was washed with saturated NaCl solution. The organic phase was dried over sodium sulfate and concentrated to dryness. Yield: 2.0 g (99%)

1. customThe solvent was removed
2. customa rotary evaporator
3. washThe aqueous phase was washed with ethyl acetate
4. extractionthe product was extracted with ethyl acetate
5. washthe organic phase was washed with saturated NaCl solution
6. dry with materialThe organic phase was dried over sodium sulfate
7. concentrationconcentrated to dryness