Hydrochloric Acid → (+/-)-2-[[2-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-3-methoxy-1-propanol

HRID 164217Notes

Reaction equation

HRID 164217 reaction equation
[ClH:28].[N:29]([O-:30])=[O:31].[NH2:1][c:2]1[s:3][c:4]2[c:5]([n:6][c:7]([S:17][CH2:18][c:19]3[c:20]([F:26])[c:21]([F:25])[cH:22][cH:23][cH:24]3)[n:8][c:9]2[NH:10][CH:11]([CH2:12][OH:13])[CH2:14][O:15][CH3:16])[n:27]1.[Na+:32].[OH2:33]>>[c:2]1([Cl:28])[s:3][c:4]2[c:5]([n:6][c:7]([S:17][CH2:18][c:19]3[c:20]([F:26])[c:21]([F:25])[cH:22][cH:23][cH:24]3)[n:8][c:9]2[NH:10][CH:11]([CH2:12][OH:13])[CH2:14][O:15][CH3:16])[n:27]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 946NitriteHCID 962WaterHCID 86635806(+/-)-2-[[2-Amino-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-3-methoxy-1-propanol

Product 1

HCID 86635807(+/-)-2-[[2-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-3-methoxy-1-propanol

Sources & evidence

ORD record
ord-e2e62518db51443bb4c20babf8b181e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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