huagongshe.com
HRID1642198

反应详情

EQUATION

反应方程式

HRID 1642198 的结构方程式

REACTANTS

反应物

1
结构：Cc1cc(N2C[C@H]3CN(C(=O)OCc4ccccc4)C[C@H]32)cnc1Cl
HCID23635534

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(N2C[C@H]3CNC[C@H]32)cnc1Cl
HCID9813282

未命名化合物

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(O)C(F)(F)F
溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

The product from Example 87A (220 mg, 0.61 mmol) in trifluoroacetic acid (6 mL) was heated at 60° C. for 2 hours, cooled to room temperature, concentrated, and purified by chromatography on silica gel (CH2Cl2:MeOH:NH4OH, 90:10:1) to afford the title compound as an oil (100 mg, 80% yield). MS (DCI/NH3) m/z 224, 226 (M+H)+.

WORKUP

后处理

  1. concentrationconcentrated
  2. custompurified by chromatography on silica gel (CH2Cl2:MeOH:NH4OH, 90:10:1)