反应详情

To a solution of 3-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester (7.6 g, 0.0176 mol) in methanol (100 mL), NaOH 2N (44.1 mL, 0.0882 mmol) was added. The mixture was gently refluxed for 8 hours, then the solvent was evaporated under vacuum, and the residual aqueous solution was diluted with water and ice. Hydrochloric acid (12 N) was added until pH 2. The yellowish solid that precipitated was collected, washed with water and dried under vacuum at 60° C. 6.5 g of the title compound was so obtained.

1. temperatureThe mixture was gently refluxed for 8 hours
2. customthe solvent was evaporated under vacuum
3. additionthe residual aqueous solution was diluted with water and ice
4. additionHydrochloric acid (12 N) was added until pH 2
5. customThe yellowish solid that precipitated was collected
6. washwashed with water
7. customdried under vacuum at 60° C