Sodium Hydroxide → HCID 178507499, compound

Participants

Reaction Steps

To a solution of 3-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester (7.6 g, 0.0176 mol) in methanol (100 mL), NaOH 2N (44.1 mL, 0.0882 mmol) was added. The mixture was gently refluxed for 8 hours, then the solvent was evaporated under vacuum, and the residual aqueous solution was diluted with water and ice. Hydrochloric acid (12 N) was added until pH 2. The yellowish solid that precipitated was collected, washed with water and dried under vacuum at 60° C. 6.5 g of the title compound was so obtained.

Provenance & Evidence