HCID 55288821, compound → HCID 57619819, compound

HRID 1642504Notes

Reaction equation

HRID 1642504 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[CH2:8][C:9]#[N:10].[CH3:11][C:12]1([N:24]2[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]2)[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13]1>>[C:9]([CH2:8][C@H:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C@@H:2]1[NH:1][CH:27]1[CH2:26][CH2:25][N:24]([C:12]2([CH3:11])[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13]2)[CH2:29][CH2:28]1)#[N:10]

Participants

3

Reactant 2

HCID 55288821HCID 55288821, compoundHCID 57619795HCID 57619795, compound

Product 1

HCID 57619819HCID 57619819, compoundYield 9%

Procedure

Following the procedure used in step D of the example 14 and starting with 2-[(1R,2S)-2-aminocyclohexyl]acetonitrile (0.342 g, 2.47 mmol) and tert-butyl 3-methyl-3-(4-oxo-1-piperidyl)pyrrolidine-1-carboxylate (0.699 g, 2.47 mmol), the title compound (0.090 g, 8.99%) was obtained after purification by preparative LC/MS (High pH). MS (M+1): 405.23.

Sources & evidence

ORD record
ord-9ec1a8d5b5e94626bf078718896b02c6
Source dataset
uspto-grants-2012_02
Patent number
US08119661B2

Reaction notes

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