反应详情

1-Acetyl-4-bromo-1H-indole-3-carbaldehyde (3.5 g, 13.2 mmol) was dissolved in CH2Cl2 (50 mL). 3-Chloroperbenzoic acid (3.9 g, 15.8 mmol) was added, and the reaction stirred 16 h at r.t. The solution was washed with sat. NaHCO3 and brine, dried (MgSO4), and concentrated. The residue was stirred with K2CO3 (100 mg) in MeOH (50 mL) for 2 min. The solution was concentrated and purified by silica gel chromatography (100% CH2Cl2) to give 880 mg (26%) of the title compound as a faintly blue solid. MS (ES) [m+H] calc'd for C10H8BrNO2, 254, 256; found 254, 256.

1. washThe solution was washed with sat. NaHCO3 and brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. stirringThe residue was stirred with K2CO3 (100 mg) in MeOH (50 mL) for 2 min
5. concentrationThe solution was concentrated
6. custompurified by silica gel chromatography (100% CH2Cl2)