2-(5-(3-(ethylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)ethanol → 2-(3-chloro-5-(3-(ethylsulfonyl)phenyl)-9H-pyrido[2,3-b]indol-8-yloxy)ethanol

Participants

Reaction Steps

The title compound was prepared from Compound 218 by using an analogous procedure to that outlined in the preparation of Compound 215. 1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1 H) 8.14 (m, 1 H) 8.06 (m, 1 H) 8.00 (m, 1 H) 7.87 (t, J=8.0 Hz, 1 H) 7.71 (d, J=4.0 Hz, 1 H) 7.21 (d, J=8.0 Hz, 1 H) 7.16 (d, J=8.0 Hz, 1 H) 4.36 (t, J=4 Hz, 2 H) 4.07 (t, J=4 Hz, 2 H) 3.30 (q, J=7.5 Hz, 2 H) 1.31 (t, J=7.5 Hz, 3 H). [M+H] calc'd for C21H20ClN2O4S, 431; found, 431.

Provenance & Evidence