L-Alanine-(R)-2-[5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrol-8-yloxy]-1-methyl-ethyl ester → (S)-3-(3-chloro-5-(3-(ethylsulfonyl)phenyl)-9H-pyrido[2,3-b]indol-8-yloxy)propyl2-aminopropanoate

Participants

Reaction Steps

The title compound was prepared from Compound 225 by using an analogous procedure to that outlined in the preparation of Compound 64. 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1 H) 8.12 (s, 1 H) 8.08 (m, 1 H) 7.97 (m, 1 H) 7.88 (t, J=7.84 Hz, 1 H) 7.69 (s, 1 H) 7.21 (d, J=8.32 Hz, 1 H) 7.16 (d, J=8.32 Hz, 1 H) 4.65 (m, 2 H) 4.42 (t, J=6.08 Hz, 2 H) 4.14 (q, J=7.32Hz, H) 3.36 (q, J=7.6 Hz, 2 H) 2.39 (m, 2 H) 1.55 (d, J=7.32 Hz, 3 H) 1.33 (t, J=7.6 Hz, 3 H). [M+H] calc'd for C25H27ClN3O5S, 516; found, 516.

Provenance & Evidence