反应详情

To a solution of chlorosulfonyl isocyanate (0.274 g, 1.93 mmol) in DCM (2 mL) is added dropwise a solution of t-butanol (0.143 g, 1.93 mmol) in 1 mL DCM. The solution is stirred at ambient temperature for 45 min. A solution of (2-benzyloxy-4-phenoxyphenylamino)acetic acid methyl ester (0.50 g, 1.38 mmol) and triethylamine (0.278 g, 2.75 mmol) in DCM (1 mL) is added dropwise. The mixture is stirred at ambient temperature for 30 min., then washed with Water. The organic phase is dried over Na2SO4 and the solvent removed under reduced pressure. The residual oil is purified by flash chromatography using DCM to elute N-(t-butoxycarbonylsulfamoyl)-N-(2-benzyloxy-4-phenoxyphenyl)glycine methyl ester as an oil: 1H NMR (CDCl3) δ 7.50 (d, J=8.84 Hz, 1H), 7.34-7.23 (m, 8H), 7.08 (t, 1H), 6.92-6.88 (m, 2H), 6.50 (d, J=2.53 Hz, 1H), 6.43 (dd, J=11.12, 2.53 Hz, 1H), 5.22 (s, 2H), 5.01 (s, 2H), 3.62 (s, 3H), 1.36 (s, 9H); MS (M−H)−=541.

1. stirringThe mixture is stirred at ambient temperature for 30 min.
2. washwashed with Water
3. dry with materialThe organic phase is dried over Na2SO4
4. customthe solvent removed under reduced pressure
5. customThe residual oil is purified by flash chromatography
6. washto elute N-(t-butoxycarbonylsulfamoyl)-N-(2-benzyloxy-4-phenoxyphenyl)glycine methyl ester as an oil