反应详情

To a solution of 2-benzyloxy-6-(3-benzyloxy-4-nitrobenzyl) -benzonitrile (0.564 g, 1.25 mmol) in EtOAc (50 mL), under N2, is added platinum oxide (0.112 g, 0.493 mmol). The suspension is stirred under an H2 atmosphere. Upon consumption of the starting material by LC/MS, the reaction mixture is passed through a plug of Celite and concentrated. Purification of the residue by flash chromatography (15-20% EtOAc/hexanes) affords 2-(4-amino-3-benzyloxybenzyl)-6-benzyloxybenzonitrile as a yellow oil: MS (M+H)+=421.

1. customUpon consumption of the starting material by LC/MS
2. concentrationconcentrated
3. customPurification of the residue by flash chromatography (15-20% EtOAc/hexanes)