反应详情

To a solution of 2-(4-methoxybenzyloxy)-5-methylbenzoic acid methyl ester (7.32 g, 25.6 mmol) in THF at 0° C. is added LiAlH4 (1 M in THF, 26 mL, 26 mmol) dropwise and the mixture is stirred for 1 h. Na2SO4 (saturated, 1 mL) is added dropwise at 0° C. and let it sit for 15 min. More THF (80 mL) is added and it is filtered. The filtrate is then concentrated and EtOAc (100 mL) is added. The organic layer is washed with brine and dried with MgSO4. It is then concentrated to give the title compound.

1. waitsit for 15 min
2. filtrationit is filtered
3. concentrationThe filtrate is then concentrated
4. additionEtOAc (100 mL) is added
5. washThe organic layer is washed with brine
6. dry with materialdried with MgSO4
7. concentrationIt is then concentrated