反应详情

温度

60 °C

To a solution of 1-benzyloxy-3-methyl-2-nitrobenzene (5.0 g, 20.6 mmol) in EtOAc (150 mL) is added SnCl2 (23.2 g, 103 mmol) and the mixture is heated at 60° C. for 72 h. The mixture is then filtered and to the filtrate is added saturated NaHCO3 and solid Na2CO3. It is then filtered again. EtOAc layer is separated and washed with brine, dried and concentrated. The residue is purified by flash chromatography to give the title compound as a yellow oil.

1. filtrationThe mixture is then filtered and to the filtrate
2. additionis added saturated NaHCO3 and solid Na2CO3
3. filtrationIt is then filtered again
4. customEtOAc layer is separated
5. washwashed with brine
6. customdried
7. concentrationconcentrated
8. customThe residue is purified by flash chromatography