Isothiocyanatopotassium → HCID 25124266, compound

HRID 1642748Notes

Reaction equation

HRID 1642748 reaction equation
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]([F:16])([F:15])[F:14])=[CH:8][CH:7]=1)=O.[N-:17]=[C:18]=[S:19].[K+]>O.Cl>[F:14][C:13]([F:16])([F:15])[O:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]2[NH:17][C:18](=[S:19])[NH:2][CH:3]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 10931372Isothiocyanatopotassium2×HCID 66754828HCID 66754828, compound

Product 1

HCID 25124266HCID 25124266, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

490 mg (1.89 mmol, 1 eq) of 2-amino-1-(4-(trifluoromethoxy)phenyl)ethanone hydrochloride and 320 mg (8.62 mmol, 4.5 eq) of potassium isothiocyanate are dissolved in 5 ml of water in the presence of 1 ml of a 2M hydrochloric acid solution. The reaction mixture is stirred at 100° C. for 16 hours. 320 mg (8.62 mmol, 4.5 eq) of potassium isothiocyanate are added and the reaction mixture is stirred at 100° C. for 16 hours. The medium is filtered and then the solid is washed with water. 320 mg of 4-(4-(trifluoromethoxy)phenyl)-1,3-dihydroimidazole-2-thione are collected.

Workup

  1. stirringthe reaction mixture is stirred at 100° C. for 16 hours
  2. filtrationThe medium is filtered
  3. washthe solid is washed with water
  4. custom320 mg of 4-(4-(trifluoromethoxy)phenyl)-1,3-dihydroimidazole-2-thione are collected

Sources & evidence

ORD record
ord-11dd9f9aac1f424882ef3739f602f8cc
Source dataset
uspto-grants-2012_02
Patent number
US08119674B2

Reaction notes

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