Hydrochloric Acid → HCID 66755297, compound

HRID 1642764Notes

Reaction equation

HRID 1642764 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:24]2[CH:28]=[N:27][N:26]=[N:25]2)=[C:6]([CH:23]=1)[CH2:7][NH:8][C:9]([C@@H:11]1[CH2:15][CH2:14][O:13][N:12]1C(OC(C)(C)C)=O)=[O:10].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:24]2[CH:28]=[N:27][N:26]=[N:25]2)=[C:6]([CH:23]=1)[CH2:7][NH:8][C:9]([C@@H:11]1[CH2:15][CH2:14][O:13][NH:12]1)=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58017527HCID 58017527, compound

Product 1

HCID 66755297HCID 66755297, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate (357 mg, 0.873 mmol) in MeOH (5 mL) was added conc. HCl (aq., 5 mL) and the mixture was stirred at rt for 1 h and then evaporated to dryness to give crude (3S)—N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]isoxazolidine-3-carboxamide hydrochloride as a solid which was used as such in the next reaction without further purification.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-fbd3b67a6a314c1082b3b0f0a27fd966
Source dataset
uspto-grants-2012_02
Patent number
US08119673B2

Reaction notes

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