反应详情

650 mg (1.60 mmol) of ethyl 5-(4-ethylphenyl)-1-[(4-cyanopiperidin-1-yl)carbonyl]piperidine-3-carboxylate were dissolved in a mixture of 20 ml of dioxane and 10 ml of water, 153 mg (6.40 mmol) of lithium hydroxide were added and the mixture was stirred at RT for 15 min. For work-up, the reaction solution was concentrated under reduced pressure, water was then added and the mixture was acidified with 1N hydrochloric acid. The precipitate formed was filtered off and dried under reduced pressure. The residue was purified by preparative HPLC. Yield: 347 mg (59% of theory)

1. additionwere added
2. concentrationFor work-up, the reaction solution was concentrated under reduced pressure, water
3. additionwas then added
4. customThe precipitate formed
5. filtrationwas filtered off
6. customdried under reduced pressure
7. customThe residue was purified by preparative HPLC