反应详情

5.0 g (35.2 mmol) of 2,3-difluorobenzonitrile were initially charged in 43 ml of ethanol, and a solution of 3.7 g (52.8 mmol) of hydroxylammonium chloride and 5.9 ml (4.3 g, 42.3 mmol) of triethylamine was added at RT. The reaction mixture was stirred at RT for 16 h, concentrated under reduced pressure, taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic extracts were dried over sodium sulphate, filtered and concentrated under reduced pressure. Yield: 5.7 g (94% of theory)

1. concentrationconcentrated under reduced pressure
2. washwashed with saturated aqueous sodium bicarbonate solution
3. dry with materialThe organic extracts were dried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure