Potassium tert-butoxide → 1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid
Reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28]([O:30]C)=[O:29])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].CC(C)([O-])C.[K+]>>[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:25])([F:26])[F:27])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28]([OH:30])=[O:29])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2]Participants
3
Procedure
1.69 g (about 2.62 mmol) of the compound from Example 107A and 2.9 g (26.2 mmol) of potassium tert-butoxide were reacted according to the General Method 9A. Yield: 1.53 g (90% of theory, 65% pure)
Sources & evidence
- ORD record
- ord-1f9e3b1b543242d4a4075725de9d20f3
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119663B2
Reaction notes
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