HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 1-[(4-cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylate | HCID 58002700 | — |
| Product | 1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002706 | — |
Reaction Steps
1.69 g (about 2.62 mmol) of the compound from Example 107A and 2.9 g (26.2 mmol) of potassium tert-butoxide were reacted according to the General Method 9A. Yield: 1.53 g (90% of theory, 65% pure)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-1f9e3b1b543242d4a4075725de9d20f3 |
| Source note | uspto-grants-2012_02 |