2-Methylpropanehydrazide → N'-(2-Methylpropanoyl)-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide
Reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26]([OH:28])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:29][CH:30]([CH3:35])[C:31]([NH:33][NH2:34])=[O:32]>>[CH3:29][CH:30]([CH3:35])[C:31]([NH:33][NH:34][C:26]([CH:11]1[CH2:12][CH:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:17][CH:16]=2)[CH2:14][N:9]([C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)=[O:8])[CH2:10]1)=[O:28])=[O:32]Participants
3
Procedure
100 mg (0.25 mmol) of the compound from Example 44A and 51 mg (0.50 mmol) of 2-methylpropanehydrazide were reacted according to the General Method 11A. Yield: 80 mg (66% of theory)
Sources & evidence
- ORD record
- ord-10950c2147b443728d816cce310234d6
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119663B2
Reaction notes
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