1,1-Dichloroacetone → HCID 58002246, compound

HRID 1642838Notes

Reaction equation

HRID 1642838 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](=[S:25])[NH2:24])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[Cl:26][CH:27](Cl)[C:28](=O)[CH3:29]>>[Cl:26][CH2:27][C:28]1[N:24]=[C:23]([CH:11]2[CH2:10][CH:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=3)[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12]2)[S:25][CH:29]=1

Participants

3

Reactant 2

HCID 105671,1-DichloroacetoneHCID 58002396HCID 58002396, compound

Product 1

HCID 58002246HCID 58002246, compound

Procedure

860 mg (2.38 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carbothioamide (Example 140A) and 362 mg (2.85 mmol) of dichloroacetone were reacted according to the General Method 3. Yield: 498 mg (43% of theory).

Sources & evidence

ORD record
ord-9f60253d9d8840829fa11983280e3340
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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