Methyl 5-bromopyridine-3-carboxylate → Methyl 5-(3-(trifluoromethyl)phenyl)nicotinate

HRID 1642840Notes

Reaction equation

HRID 1642840 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1>>[F:12][C:13]([F:24])([F:23])[C:14]1[CH:19]=[C:18]([C:2]2[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=[N:4][CH:3]=2)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 699336Methyl 5-bromopyridine-3-carboxylateHCID 27343883-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 20099856Methyl 5-(3-(trifluoromethyl)phenyl)nicotinate

Procedure

10.0 g (46.3 mmol) of methyl 5-bromonicotinate and 10.6 g (55.5 mmol) of 3-trifluoromethylphenylboronic acid were reacted according to the General Method 1A. Yield: 11.9 g (91% of theory)

Sources & evidence

ORD record
ord-8432b17786304ecbbe762af537f551ba
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…