HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromopyridine-3-carboxylate → Methyl 5-(3-(trifluoromethyl)phenyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Reactant | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| Product | Methyl 5-(3-(trifluoromethyl)phenyl)nicotinate | HCID 20099856 | — |
Reaction Steps
10.0 g (46.3 mmol) of methyl 5-bromonicotinate and 10.6 g (55.5 mmol) of 3-trifluoromethylphenylboronic acid were reacted according to the General Method 1A. Yield: 11.9 g (91% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8432b17786304ecbbe762af537f551ba |
| Source note | uspto-grants-2012_02 |